ZFP41

Across TCGA patient cohorts, ZFP41 mutation is significantly associated with the total protein of many other genes, with 17 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible ZFP41-associated genes across cancer lineages are FOXO3a_pS318_S321, PEA-15_pS116, and 14-3-3_beta. Each is linked with ZFP41 in more than 1 cancer types. Because this analysis shows association rather than direction, both ZFP41-to-partner and partner-to-ZFP41 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, FOXO3a_pS318_S321 grouped by ZFP41-low versus ZFP41-high in SKCM.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ZFP41→partner) and Y-score (partner→ZFP41) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SKCM	FOXO3a_pS318_S321 →	+0.332	+2.824	<.001	.034	3	1
SKCM	PEA-15_pS116 →	+0.394	+3.000	.014	.035	3	1
UCEC	14-3-3_beta →	-0.099	-2.973	.041	.035	3	1
UCEC	Ku80 →	+0.378	+2.472	<.001	.011	3	1
UCEC	Notch1 →	+0.257	+3.469	<.001	.002	3	1
UCEC	PCNA →	+0.208	+2.459	.046	.020	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 17 associations by consensus.

FOXO3a_pS318_S321 by ZFP41 expression — SKCM

Explore this box plot interactively →