ZFP41

Across TCGA cell cohorts, ZFP41 RNA expression is significantly associated with the go_rna of many other GO terms, with 4,110 significant associations in total. BLOOD_Lymphoma shows the largest number of these associations.

The most reproducible ZFP41-associated GO terms across cancer lineages are Positive regulation of intracellular steroid hormone receptor signaling pathway, Positive regulation of intracellular estrogen receptor signaling pathway, and Regulation of pattern recognition receptor signaling pathway. Each is linked with ZFP41 in more than 15 cancer types. Because this analysis shows association rather than direction, both ZFP41-to-partner and partner-to-ZFP41 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Positive regulation of intracellular steroid hormone receptor signaling pathway grouped by ZFP41-low versus ZFP41-high in BONE.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (ZFP41→partner) and Y-score (partner→ZFP41) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BONE	Positive regulation of intracellular steroid hormone receptor signaling pathway →	+0.159	+1.021	.001	.002	3	16
BONE	Positive regulation of intracellular estrogen receptor signaling pathway →	+0.232	+1.380	<.001	<.001	3	15
UPPER_AERODIGESTIVE_TRACT	Regulation of pattern recognition receptor signaling pathway →	+0.083	+1.305	<.001	<.001	3	15
UPPER_AERODIGESTIVE_TRACT	Regulation of translational initiation →	+0.100	+0.977	<.001	.004	3	15
BONE	Pre-mRNA catabolic process →	+0.201	+0.999	<.001	<.001	3	15
BONE	mRNA transcription by RNA polymerase II →	+0.082	+0.918	.001	.001	3	15

Each partner links to its Q-omics profile. Showing the 6 strongest of 4,110 associations by consensus.

Positive regulation of intracellular steroid hormone receptor signaling pathway by ZFP41 expression — BONE

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