ZDHHC21

Across TCGA patient cohorts, ZDHHC21 mutation is significantly associated with the total protein of many other genes, with 16 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible ZDHHC21-associated genes across cancer lineages are Rad50, ATM, and ERK2. Each is linked with ZDHHC21 in more than 1 cancer types. Because this analysis shows association rather than direction, both ZDHHC21-to-partner and partner-to-ZDHHC21 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Rad50 grouped by ZDHHC21-low versus ZDHHC21-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ZDHHC21→partner) and Y-score (partner→ZDHHC21) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	Rad50 →	-0.225	-2.115	.033	.019	3	2
UCEC	ATM →	-0.477	-2.115	.016	.019	3	2
UCEC	ERK2 →	+0.180	+2.115	.032	.019	3	1
UCEC	IGFBP2 →	-0.754	-2.115	.007	.019	3	1
UCEC	Ku80 →	+0.288	+1.884	.005	.030	3	1
UCEC	p70-S6K →	+0.196	+2.142	.020	.010	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 16 associations by consensus.

Rad50 by ZDHHC21 expression — UCEC

Explore this box plot interactively →