ZDHHC21

Across TCGA pan-cancer cohorts, ZDHHC21 RNA differs between tumor and matched normal tissue in 9 of 18 cancer types tested, making tumor–normal expression one of ZDHHC21’s most consistent transcriptional readouts.

The strongest signal is observed in lung squamous cell carcinoma (LUSC), where ZDHHC21 RNA is repressed in tumor relative to normal tissue. In most cancer types ZDHHC21 is over-expressed in tumor, although a few such as LUSC and KIRC show the opposite, repressed pattern.

LUSC, KIRC, and CHOL are the cancer types where ZDHHC21 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in ZDHHC21 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
LUSC	All	II,III,IV	−0.677	<.001	7	view →
KIRC	Male	III,IV	−0.574	<.001	7	view →
CHOL	Male	All	+1.725	<.001	5	view →
COAD	Female	All	−0.734	<.001	4	view →
KIRP	All	All	−0.458	<.001	4	view →
LIHC	All	All	+0.333	<.001	4	view →
THCA	All	All	−0.316	.001	4	view →
PRAD	All	All	+0.363	<.001	2	view →
BRCA	All	II,III,IV	+0.246	.023	2	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 9 strongest of 9 lineages.

ZDHHC21–LUSC

Open the LUSC breakdown →