ZDHHC21

Across TCGA cell cohorts, ZDHHC21 mutation is significantly associated with the RNA expression of many other genes, with 3 significant associations in total. LUNG_NSCLC_LUAD shows the largest number of these associations.

The most reproducible ZDHHC21-associated genes across cancer lineages are OR10AG1, PABPC1L2A, and OR14A2. Each is linked with ZDHHC21 in more than 1 cancer types. Because this analysis shows association rather than direction, both ZDHHC21-to-partner and partner-to-ZDHHC21 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, OR10AG1 grouped by ZDHHC21-low versus ZDHHC21-high in LUNG_NSCLC_LUAD.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ZDHHC21→partner) and Y-score (partner→ZDHHC21) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_NSCLC_LUAD	OR10AG1 →	+0.043	+5.662	<.001	.002	3	1
LUNG_NSCLC_LUAD	PABPC1L2A →	+0.045	+4.887	<.001	.009	3	1
LUNG_NSCLC_LUAD	OR14A2 →	+0.022	+5.228	<.001	.005	3	1

Each partner links to its Q-omics profile. Showing the 3 strongest of 3 associations by consensus.

OR10AG1 by ZDHHC21 expression — LUNG_NSCLC_LUAD

Explore this box plot interactively →