ZDHHC1

Across TCGA patient cohorts, ZDHHC1 mutation is significantly associated with the RNA expression of many other genes, with 1,635 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible ZDHHC1-associated genes across cancer lineages are RN7SL248P, MIR3188, and KRTAP13-6P. Each is linked with ZDHHC1 in more than 2 cancer types. Because this analysis shows association rather than direction, both ZDHHC1-to-partner and partner-to-ZDHHC1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, RN7SL248P grouped by ZDHHC1-low versus ZDHHC1-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ZDHHC1→partner) and Y-score (partner→ZDHHC1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	RN7SL248P →	+0.057	+3.137	<.001	.005	3	3
UCEC	MIR3188 →	+0.347	+2.120	.005	.001	3	2
SKCM	KRTAP13-6P →	+0.087	+5.219	<.001	.002	3	2
UCEC	MTATP6P21 →	+0.339	+2.552	<.001	<.001	3	2
UCEC	LINC01072 →	+0.139	+2.488	<.001	<.001	3	2
UCEC	RNU6-718P →	+0.122	+3.292	.001	.003	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 1,635 associations by consensus.

RN7SL248P by ZDHHC1 expression — UCEC

Explore this box plot interactively →