ZC3H18

Across TCGA patient cohorts, ZC3H18 mutation is significantly associated with the RNA expression of many other genes, with 5,193 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible ZC3H18-associated genes across cancer lineages are MICU1, BLOC1S2, and FUT11. Each is linked with ZC3H18 in more than 2 cancer types. Because this analysis shows association rather than direction, both ZC3H18-to-partner and partner-to-ZC3H18 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, MICU1 grouped by ZC3H18-low versus ZC3H18-high in SKCM.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ZC3H18→partner) and Y-score (partner→ZC3H18) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SKCM	MICU1 →	+0.579	+2.926	<.001	<.001	3	3
SKCM	BLOC1S2 →	+0.567	+3.523	<.001	.002	3	3
COAD	FUT11 →	+0.453	+3.382	.006	.004	3	3
SKCM	SENP3-EIF4A1 →	+0.232	+2.680	<.001	<.001	3	3
UCEC	HAUS1 →	+0.450	+1.461	<.001	<.001	3	3
UCEC	SKA1 →	+0.662	+1.936	<.001	<.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 5,193 associations by consensus.

MICU1 by ZC3H18 expression — SKCM

Explore this box plot interactively →