ZC3H18

Across TCGA pan-cancer cohorts, ZC3H18 RNA differs between tumor and matched normal tissue in 12 of 18 cancer types tested, making tumor–normal expression one of ZC3H18’s most consistent transcriptional readouts.

The strongest signal is observed in kidney renal papillary cell carcinoma (KIRP), where ZC3H18 RNA is more highly expressed in tumor relative to normal tissue. In most cancer types ZC3H18 is over-expressed in tumor, although a few such as THCA show the opposite, repressed pattern.

KIRP, HNSC, and COAD are the cancer types where ZC3H18 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in ZC3H18 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
KIRP	All	IV	+1.410	<.001	11	view →
HNSC	Male	III,IV	+0.871	<.001	11	view →
COAD	All	IV	+0.700	<.001	10	view →
KIRC	Female	All	+0.503	<.001	9	view →
LIHC	Female	All	+0.685	<.001	8	view →
BLCA	All	All	+0.491	<.001	8	view →
STAD	Male	II,III,IV	+1.143	<.001	6	view →
CHOL	Male	All	+1.778	<.001	5	view →
THCA	All	II,III,IV	−0.320	.005	5	view →
ESCA	All	All	+0.870	.001	4	view →
LUSC	Male	All	+0.416	<.001	4	view →
LUAD	All	All	+0.184	.026	1	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 12 strongest of 12 lineages.

ZC3H18–KIRP

Open the KIRP breakdown →