ZC3H12D

Across TCGA patient cohorts, ZC3H12D mutation is significantly associated with the total protein of many other genes, with 47 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible ZC3H12D-associated genes across cancer lineages are GSK-3a-b_pS21_S9, p38-MAPK_pT180_Y182, and Rab25. Each is linked with ZC3H12D in more than 1 cancer types. Because this analysis shows association rather than direction, both ZC3H12D-to-partner and partner-to-ZC3H12D results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, GSK-3a-b_pS21_S9 grouped by ZC3H12D-low versus ZC3H12D-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ZC3H12D→partner) and Y-score (partner→ZC3H12D) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	GSK-3a-b_pS21_S9 →	-0.559	-3.321	.002	.009	3	2
UCEC	p38-MAPK_pT180_Y182 →	-0.737	-2.893	<.001	.001	3	2
UCEC	Rab25 →	-0.356	-2.459	.011	.019	3	2
UCEC	A-Raf_pS299 →	-0.117	-2.222	.020	.011	3	1
UCEC	ERK2 →	+0.181	+2.321	.027	.034	3	1
UCEC	FoxM1 →	+0.222	+2.222	.043	.011	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 47 associations by consensus.

GSK-3a-b_pS21_S9 by ZC3H12D expression — UCEC

Explore this box plot interactively →