ZC3H12C

Across TCGA cell cohorts, ZC3H12C mutation is significantly associated with the RNA expression of many other genes, with 73 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible ZC3H12C-associated genes across cancer lineages are OR1J4, CYP11B1, and KRTAP2-4. Each is linked with ZC3H12C in more than 1 cancer types. Because this analysis shows association rather than direction, both ZC3H12C-to-partner and partner-to-ZC3H12C results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, OR1J4 grouped by ZC3H12C-low versus ZC3H12C-high in URINARY_TRACT.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ZC3H12C→partner) and Y-score (partner→ZC3H12C) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
URINARY_TRACT	OR1J4 →	+0.037	+3.584	.007	.009	3	2
SOFT_TISSUE	CYP11B1 →	+0.023	+5.977	<.001	.001	3	1
SOFT_TISSUE	KRTAP2-4 →	+0.147	+4.930	<.001	.008	3	1
SOFT_TISSUE	PRAMEF18 →	+0.026	+4.930	<.001	.008	3	1
URINARY_TRACT	KCNK10 →	+0.414	+3.836	<.001	.004	3	1
URINARY_TRACT	C1orf185 →	+0.077	+3.584	.001	.005	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 73 associations by consensus.

OR1J4 by ZC3H12C expression — URINARY_TRACT

Explore this box plot interactively →