ZC3H12C

Across TCGA pan-cancer cohorts, ZC3H12C RNA differs between tumor and matched normal tissue in 11 of 18 cancer types tested, making tumor–normal expression one of ZC3H12C’s most consistent transcriptional readouts.

The strongest signal is observed in colon adenocarcinoma (COAD), where ZC3H12C RNA is repressed in tumor relative to normal tissue. In most cancer types ZC3H12C is over-expressed in tumor, although a few such as COAD and BLCA show the opposite, repressed pattern.

COAD, BLCA, and HNSC are the cancer types where ZC3H12C tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in ZC3H12C RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
COAD	All	IV	−1.485	<.001	12	view →
BLCA	Male	All	−1.113	<.001	10	view →
HNSC	All	III,IV	+0.770	<.001	10	view →
THCA	Male	III,IV	−1.222	<.001	9	view →
UCEC	All	All	−1.639	<.001	6	view →
BRCA	All	III,IV	−1.402	<.001	6	view →
LUAD	Female	II,III,IV	−0.876	<.001	6	view →
LUSC	All	All	−0.548	<.001	4	view →
READ	All	All	−1.072	.016	2	view →
CHOL	All	All	+0.567	.024	1	view →
KIRP	Male	All	−0.417	.020	1	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 11 strongest of 11 lineages.

ZC3H12C–COAD

Open the COAD breakdown →