ZC3H12A

Across TCGA patient cohorts, ZC3H12A mutation is significantly associated with the RNA expression of many other genes, with 3,391 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible ZC3H12A-associated genes across cancer lineages are RN7SKP60, TMEM184CP1, and HMGN2P24. Each is linked with ZC3H12A in more than 2 cancer types. Because this analysis shows association rather than direction, both ZC3H12A-to-partner and partner-to-ZC3H12A results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, RN7SKP60 grouped by ZC3H12A-low versus ZC3H12A-high in BRCA.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ZC3H12A→partner) and Y-score (partner→ZC3H12A) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BRCA	RN7SKP60 →	+0.184	+5.342	<.001	.001	3	3
BRCA	TMEM184CP1 →	+0.077	+5.133	<.001	.002	3	3
UCEC	HMGN2P24 →	+0.234	+1.617	.004	.007	3	3
SKCM	SERPINA7P1 →	+0.025	+4.411	<.001	.005	3	3
BRCA	CASP1P1 →	+0.278	+4.786	<.001	.004	3	2
CESC	RNU6-1308P →	+0.333	+4.559	<.001	.006	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 3,391 associations by consensus.

RN7SKP60 by ZC3H12A expression — BRCA

Explore this box plot interactively →