ZC3H12A

Across TCGA pan-cancer cohorts, ZC3H12A RNA is linked to patient survival in 29 of 34 cancer types, making it the most broadly survival-associated ZC3H12A data layer compared with 6 for mutation status and 5 for mass-spec protein.

The strongest signal is observed in adrenocortical carcinoma (ACC), where higher ZC3H12A RNA is associated with worse overall survival. In most high-consensus cancer types, elevated ZC3H12A expression acts as an unfavorable survival marker, although some lineages such as SKCM and MESO show a favorable association.

ACC, KIRC, and SKCM are the cancer types where ZC3H12A RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
ACC	OS	Tertile	All	0.388	0.768	<.001	85	view →
KIRC	DFS	Median	II,III,IV	0.426	0.613	<.001	79	view →
SKCM	OS	Quartile	II,III,IV	0.652	0.336	.004	64	view →
LGG	OS	Median	All	0.751	0.863	<.001	50	view →
UVM	OS	Tertile	III,IV	0.498	1.000	.005	41	view →
MESO	OS	Tertile	IV	0.946	0.405	.010	38	view →
THCA	DFS	Tertile	II,III,IV	0.607	0.950	<.001	36	view →
KIRP	DFS	Tertile	III,IV	0.100	0.539	.003	26	view →
GBM	DFS	Tertile	All	0.175	0.424	.001	24	view →
UCEC	DFS	Quartile	II,III,IV	0.923	0.734	.004	22	view →
DLBC	OS	Quartile	II,III,IV	0.642	0.937	.022	19	view →
SCLC	DFS	Median	All	0.716	0.526	.005	15	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 29 lineages.

ZC3H12A–ACC (OS)

Open the ACC breakdown →