ZC3H12A

Across TCGA pan-cancer cohorts, ZC3H12A RNA differs between tumor and matched normal tissue in 12 of 18 cancer types tested, making tumor–normal expression one of ZC3H12A’s most consistent transcriptional readouts.

The strongest signal is observed in kidney chromophobe (KICH), where ZC3H12A RNA is repressed in tumor relative to normal tissue. In most cancer types ZC3H12A is over-expressed in tumor, although a few such as KICH and BRCA show the opposite, repressed pattern.

KICH, BRCA, and COAD are the cancer types where ZC3H12A tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in ZC3H12A RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
KICH	All	III,IV	−2.301	<.001	10	view →
BRCA	Female	II,III,IV	−0.509	<.001	8	view →
COAD	All	II,III,IV	+0.758	<.001	7	view →
BLCA	Female	III,IV	−1.535	.006	4	view →
PAAD	All	All	+0.615	<.001	4	view →
ESCA	All	All	+1.910	.003	2	view →
CHOL	All	All	+1.518	.002	2	view →
READ	All	All	+1.093	.012	2	view →
LUSC	Male	II,III,IV	−1.057	.009	2	view →
LUAD	Male	All	−0.833	.034	2	view →
STAD	Male	All	+0.781	.026	2	view →
KIRC	Male	IV	+0.774	.015	1	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 12 strongest of 12 lineages.

ZC3H12A–KICH

Open the KICH breakdown →