ZC3H12A

Across TCGA cell cohorts, ZC3H12A mutation is significantly associated with the RNA expression of many other genes, with 20 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible ZC3H12A-associated genes across cancer lineages are SPACA1, GALR3, and KRT84. Each is linked with ZC3H12A in more than 1 cancer types. Because this analysis shows association rather than direction, both ZC3H12A-to-partner and partner-to-ZC3H12A results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, SPACA1 grouped by ZC3H12A-low versus ZC3H12A-high in OVARY.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ZC3H12A→partner) and Y-score (partner→ZC3H12A) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OVARY	SPACA1 →	+0.017	+4.807	<.001	.003	3	1
LARGE_INTESTINE	GALR3 →	+0.102	+3.646	<.001	.002	3	1
LARGE_INTESTINE	KRT84 →	+0.343	+3.754	.002	.002	3	1
LARGE_INTESTINE	NTSR2 →	+0.052	+2.793	<.001	.002	3	1
LARGE_INTESTINE	FBXL14 →	+0.841	+3.067	.001	.009	3	1
LARGE_INTESTINE	REG3A →	+2.037	+3.807	<.001	.001	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 20 associations by consensus.

SPACA1 by ZC3H12A expression — OVARY

Explore this box plot interactively →