ZC3H11A

Across TCGA patient cohorts, ZC3H11A mutation is significantly associated with the RNA expression of many other genes, with 3,688 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible ZC3H11A-associated genes across cancer lineages are RNU6-275P, GZMH, and SLA2. Each is linked with ZC3H11A in more than 1 cancer types. Because this analysis shows association rather than direction, both ZC3H11A-to-partner and partner-to-ZC3H11A results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, RNU6-275P grouped by ZC3H11A-low versus ZC3H11A-high in BRCA.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ZC3H11A→partner) and Y-score (partner→ZC3H11A) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BRCA	RNU6-275P →	+0.285	+4.431	<.001	.008	3	2
UCEC	GZMH →	+1.065	+2.565	<.001	<.001	3	2
UCEC	SLA2 →	+0.559	+2.555	<.001	<.001	3	2
UCEC	LILRB5 →	+0.289	+1.235	<.001	.008	3	2
UCEC	CRTAM →	+0.335	+1.642	.001	<.001	3	2
UCEC	PDHX →	+0.438	+1.696	<.001	<.001	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 3,688 associations by consensus.

RNU6-275P by ZC3H11A expression — BRCA

Explore this box plot interactively →