ZC3H11A

Across TCGA pan-cancer cohorts, ZC3H11A RNA differs between tumor and matched normal tissue in 12 of 18 cancer types tested, making tumor–normal expression one of ZC3H11A’s most consistent transcriptional readouts.

The strongest signal is observed in head and neck squamous cell carcinoma (HNSC), where ZC3H11A RNA is more highly expressed in tumor relative to normal tissue. In most cancer types ZC3H11A is over-expressed in tumor, although a few such as THCA and KICH show the opposite, repressed pattern.

HNSC, LIHC, and THCA are the cancer types where ZC3H11A tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in ZC3H11A RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
HNSC	Female	III,IV	+1.148	<.001	12	view →
LIHC	All	II,III,IV	+0.994	<.001	8	view →
THCA	All	All	−0.417	<.001	8	view →
KICH	Female	All	−1.266	<.001	7	view →
BLCA	All	III,IV	+0.483	.002	6	view →
STAD	All	II,III,IV	+0.703	.006	5	view →
LUSC	Male	All	+0.508	<.001	5	view →
LUAD	All	All	+0.461	<.001	5	view →
BRCA	All	II,III,IV	+0.237	.004	4	view →
CHOL	Male	All	+2.135	<.001	3	view →
COAD	Male	All	+0.364	.009	2	view →
ESCA	All	All	+0.504	.041	1	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 12 strongest of 12 lineages.

ZC3H11A–HNSC

Open the HNSC breakdown →