ZC3H11A

Across TCGA pan-cancer cohorts, ZC3H11A RNA is linked to patient survival in 27 of 34 cancer types, making it the most broadly survival-associated ZC3H11A data layer compared with 11 for mutation status and 6 for mass-spec protein.

The strongest signal is observed in adrenocortical carcinoma (ACC), where higher ZC3H11A RNA is associated with worse disease-free survival. In most high-consensus cancer types, elevated ZC3H11A expression acts as an unfavorable survival marker, although some lineages such as KIRC and GBM show a favorable association.

ACC, UVM, and KIRP are the cancer types where ZC3H11A RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
ACC	DFS	Median	All	0.169	0.719	<.001	114	view →
UVM	DFS	Quartile	II,III,IV	0.275	0.823	<.001	60	view →
KIRP	OS	Median	II,III,IV	0.459	0.932	.002	50	view →
LGG	DFS	Median	All	0.783	0.879	<.001	43	view →
KIRC	DFS	Quartile	All	0.894	0.723	.008	21	view →
GBM	OS	Median	All	0.571	0.258	<.001	18	view →
CESC	DFS	Median	All	0.766	0.879	.001	18	view →
KICH	DFS	Tertile	II,III,IV	0.508	0.887	.016	14	view →
ESCA	OS	Median	II,III,IV	0.618	0.396	.030	13	view →
HNSC	DFS	Median	IV	0.439	0.289	.009	13	view →
PAAD	OS	Quartile	II,III,IV	0.550	0.263	.006	12	view →
MESO	DFS	Tertile	IV	0.195	0.580	.033	12	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 27 lineages.

ZC3H11A–ACC (DFS)

Open the ACC breakdown →