ZC3H11A

Across TCGA patient cohorts, ZC3H11A mutation is significantly associated with the total protein of many other genes, with 42 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible ZC3H11A-associated genes across cancer lineages are Gab2, Notch1, and PDCD4. Each is linked with ZC3H11A in more than 2 cancer types. Because this analysis shows association rather than direction, both ZC3H11A-to-partner and partner-to-ZC3H11A results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Gab2 grouped by ZC3H11A-low versus ZC3H11A-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ZC3H11A→partner) and Y-score (partner→ZC3H11A) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	Gab2 →	+0.304	+1.643	.006	.003	3	3
UCEC	Notch1 →	+0.155	+2.515	<.001	<.001	3	3
UCEC	PDCD4 →	-0.503	-1.415	<.001	.010	3	3
UCEC	ATM →	-0.440	-2.401	.001	.002	3	3
UCEC	FoxM1 →	+0.179	+1.201	.026	.028	3	2
UCEC	HER3_pY1289 →	+0.057	+1.228	.031	.018	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 42 associations by consensus.

Gab2 by ZC3H11A expression — UCEC

Explore this box plot interactively →