ZBTB7A

Across TCGA patient cohorts, ZBTB7A mutation is significantly associated with the total protein of many other genes, with 35 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible ZBTB7A-associated genes across cancer lineages are p38-MAPK_pT180_Y182, A-Raf_pS299, and Rictor_pT1135. Each is linked with ZBTB7A in more than 2 cancer types. Because this analysis shows association rather than direction, both ZBTB7A-to-partner and partner-to-ZBTB7A results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, p38-MAPK_pT180_Y182 grouped by ZBTB7A-low versus ZBTB7A-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ZBTB7A→partner) and Y-score (partner→ZBTB7A) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	p38-MAPK_pT180_Y182 →	-0.553	-2.459	.002	.019	3	3
UCEC	A-Raf_pS299 →	-0.151	-2.321	.002	.034	3	2
UCEC	Rictor_pT1135 →	-0.112	-2.459	.008	.019	3	2
UCEC	Src_pY527 →	-0.408	-3.321	.021	.009	3	2
UCEC	eEF2 →	+0.450	+3.169	.002	.018	3	1
UCEC	EGFR_pY1068 →	-0.332	-3.584	.001	.002	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 35 associations by consensus.

p38-MAPK_pT180_Y182 by ZBTB7A expression — UCEC

Explore this box plot interactively →