ZBTB7A

Across TCGA pan-cancer cohorts, ZBTB7A RNA differs between tumor and matched normal tissue in 12 of 18 cancer types tested, making tumor–normal expression one of ZBTB7A’s most consistent transcriptional readouts.

The strongest signal is observed in liver hepatocellular carcinoma (LIHC), where ZBTB7A RNA is more highly expressed in tumor relative to normal tissue. In most cancer types ZBTB7A is over-expressed in tumor, although a few such as UCEC and BLCA show the opposite, repressed pattern.

LIHC, UCEC, and BLCA are the cancer types where ZBTB7A tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in ZBTB7A RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
LIHC	Male	II,III,IV	+0.845	<.001	9	view →
UCEC	All	II,III,IV	−0.934	<.001	6	view →
BLCA	All	All	−0.479	.002	6	view →
BRCA	All	All	+0.115	.035	4	view →
CHOL	Male	All	+2.011	<.001	3	view →
LUAD	All	All	−0.383	<.001	3	view →
COAD	Female	All	−0.304	.007	3	view →
STAD	Male	IV	+1.320	.030	2	view →
PAAD	All	All	+0.519	.005	2	view →
READ	All	All	−0.368	.031	1	view →
THCA	Male	II,III,IV	−0.226	.046	1	view →
KIRC	All	All	+0.150	.040	1	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 12 strongest of 12 lineages.

ZBTB7A–LIHC

Open the LIHC breakdown →