ZBTB7A

Across TCGA pan-cancer cohorts, ZBTB7A RNA is linked to patient survival in 26 of 34 cancer types, making it the most broadly survival-associated ZBTB7A data layer compared with 4 for mutation status and 2 for mass-spec protein.

The strongest signal is observed in stomach adenocarcinoma (STAD), where higher ZBTB7A RNA is associated with better disease-free survival. In most high-consensus cancer types, elevated ZBTB7A expression acts as an unfavorable survival marker, although some lineages such as STAD and KIRC show a favorable association.

STAD, KIRC, and LUAD are the cancer types where ZBTB7A RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
STAD	DFS	Median	All	0.728	0.586	<.001	74	view →
KIRC	OS	Median	All	0.703	0.539	<.001	72	view →
LUAD	DFS	Median	All	0.244	0.462	.002	55	view →
LGG	OS	Median	All	0.754	0.864	<.001	41	view →
MESO	OS	Tertile	All	0.228	0.781	.006	40	view →
UCEC	DFS	Quartile	III,IV	0.770	0.363	.004	36	view →
UCS	DFS	Median	II,III,IV	0.267	0.588	.004	36	view →
UVM	DFS	Tertile	II,III,IV	0.314	0.656	.002	34	view →
HNSC	DFS	Quartile	IV	0.584	0.386	.007	29	view →
PAAD	OS	Median	All	0.318	0.662	.001	27	view →
SCLC	DFS	Quartile	All	1.000	0.645	.012	20	view →
DLBC	DFS	Median	All	0.613	0.922	.006	18	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 26 lineages.

ZBTB7A–STAD (DFS)

Open the STAD breakdown →