ZBTB45

Across TCGA patient cohorts, ZBTB45 mutation is significantly associated with the RNA expression of many other genes, with 1,726 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible ZBTB45-associated genes across cancer lineages are RNU6-434P, RNA5SP388, and HIF1AP1. Each is linked with ZBTB45 in more than 1 cancer types. Because this analysis shows association rather than direction, both ZBTB45-to-partner and partner-to-ZBTB45 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, RNU6-434P grouped by ZBTB45-low versus ZBTB45-high in LGG.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ZBTB45→partner) and Y-score (partner→ZBTB45) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LGG	RNU6-434P →	+0.441	+5.392	<.001	.005	3	2
LUAD	RNA5SP388 →	+0.513	+7.930	<.001	.008	3	2
UCEC	HIF1AP1 →	+0.316	+1.634	.001	.009	3	2
BLCA	RNU6-23P →	+0.442	+4.850	<.001	<.001	3	2
COAD	RNA5SP235 →	+0.883	+6.122	<.001	.002	3	2
COAD	RNU6-308P →	+1.834	+5.693	<.001	.003	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 1,726 associations by consensus.

RNU6-434P by ZBTB45 expression — LGG

Explore this box plot interactively →