ZBTB22

Across TCGA patient cohorts, ZBTB22 mutation is significantly associated with the RNA expression of many other genes, with 1,231 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible ZBTB22-associated genes across cancer lineages are SRIP1, PPIAP63, and OR4A42P. Each is linked with ZBTB22 in more than 2 cancer types. Because this analysis shows association rather than direction, both ZBTB22-to-partner and partner-to-ZBTB22 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, SRIP1 grouped by ZBTB22-low versus ZBTB22-high in HNSC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ZBTB22→partner) and Y-score (partner→ZBTB22) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
HNSC	SRIP1 →	+0.123	+5.936	<.001	.001	3	3
THCA	PPIAP63 →	+0.114	+7.962	<.001	.007	3	2
THCA	OR4A42P →	+0.034	+7.962	<.001	.007	3	2
HNSC	OR8G2P →	+0.041	+5.936	<.001	.001	3	2
HNSC	CYLC1 →	+0.016	+5.111	.009	.004	3	2
HNSC	RNU6-800P →	+0.362	+4.565	.001	.004	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 1,231 associations by consensus.

SRIP1 by ZBTB22 expression — HNSC

Explore this box plot interactively →