ZBTB22

Across TCGA pan-cancer cohorts, ZBTB22 RNA is linked to patient survival in 22 of 34 cancer types, making it the most broadly survival-associated ZBTB22 data layer compared with 7 for mutation status.

The strongest signal is observed in colon adenocarcinoma (COAD), where higher ZBTB22 RNA is associated with worse disease-free survival. In most high-consensus cancer types, elevated ZBTB22 expression acts as an unfavorable survival marker, although some lineages such as KIRC and ESCA show a favorable association.

COAD, KIRC, and ESCA are the cancer types where ZBTB22 RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
COAD	DFS	Median	All	0.724	0.836	<.001	64	view →
KIRC	OS	Quartile	All	0.747	0.440	<.001	42	view →
ESCA	DFS	Tertile	II,III,IV	1.000	0.128	.005	41	view →
THYM	DFS	Tertile	III,IV	1.000	0.232	.003	38	view →
READ	OS	Quartile	IV	1.000	0.367	.004	33	view →
ACC	DFS	Quartile	All	0.269	0.807	<.001	21	view →
SCLC	DFS	Median	II,III,IV	0.819	0.205	.004	18	view →
LUAD	DFS	Median	III,IV	0.456	0.165	.010	18	view →
UCEC	OS	Tertile	IV	0.915	0.600	.010	16	view →
LUSC	DFS	Tertile	III,IV	0.519	1.000	.019	7	view →
TGCT	DFS	Quartile	All	0.706	0.915	.022	6	view →
PAAD	OS	Median	II,III,IV	0.651	0.460	.006	5	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 22 lineages.

ZBTB22–COAD (DFS)

Open the COAD breakdown →