ZBTB1

Across TCGA cell cohorts, ZBTB1 mutation is significantly associated with the RNA expression of many other genes, with 23 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible ZBTB1-associated genes across cancer lineages are CYLC1, FAM205C, and MEIKIN. Each is linked with ZBTB1 in more than 1 cancer types. Because this analysis shows association rather than direction, both ZBTB1-to-partner and partner-to-ZBTB1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, CYLC1 grouped by ZBTB1-low versus ZBTB1-high in SKIN.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ZBTB1→partner) and Y-score (partner→ZBTB1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SKIN	CYLC1 →	+0.013	+5.415	<.001	.004	3	1
SKIN	FAM205C →	+0.045	+4.977	<.001	.007	3	1
SKIN	MEIKIN →	+0.022	+5.415	<.001	.004	3	1
SKIN	RBMY1B →	+1.113	+4.977	<.001	.007	3	1
BLOOD_Leukemia	GJD4 →	+0.041	+4.108	<.001	.003	3	1
BLOOD_Leukemia	OR10Q1 →	+0.019	+4.384	<.001	.006	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 23 associations by consensus.

CYLC1 by ZBTB1 expression — SKIN

Explore this box plot interactively →