ZBTB1

Across TCGA pan-cancer cohorts, ZBTB1 RNA is linked to patient survival in 22 of 34 cancer types, making it the most broadly survival-associated ZBTB1 data layer compared with 5 for mutation status and 3 for mass-spec protein.

The strongest signal is observed in head and neck squamous cell carcinoma (HNSC), where higher ZBTB1 RNA is associated with better disease-free survival. In most high-consensus cancer types, elevated ZBTB1 expression acts as an unfavorable survival marker, although some lineages such as HNSC and KIRC show a favorable association.

HNSC, KIRC, and ACC are the cancer types where ZBTB1 RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
HNSC	DFS	Median	IV	0.659	0.493	.002	70	view →
KIRC	DFS	Median	All	0.727	0.516	<.001	64	view →
ACC	DFS	Tertile	All	0.475	0.802	.002	45	view →
UVM	DFS	Quartile	III,IV	0.170	0.735	.007	36	view →
BRCA	DFS	Quartile	III,IV	0.950	0.791	.004	33	view →
SKCM	DFS	Quartile	All	0.277	0.168	.001	25	view →
UCS	DFS	Median	IV	0.952	0.367	.001	24	view →
LUSC	OS	Median	III,IV	0.476	0.938	.011	19	view →
KICH	DFS	Median	III,IV	0.279	0.857	.007	15	view →
ESCA	DFS	Tertile	IV	0.221	0.692	.024	12	view →
THCA	OS	Median	All	0.963	1.000	.012	12	view →
LIHC	DFS	Tertile	All	0.153	0.388	.009	12	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 22 lineages.

ZBTB1–HNSC (DFS)

Open the HNSC breakdown →