ZBP1

Across TCGA patient cohorts, ZBP1 mutation is significantly associated with the RNA expression of many other genes, with 3,333 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible ZBP1-associated genes across cancer lineages are GMEB1, CTU2, and IP6K1. Each is linked with ZBP1 in more than 2 cancer types. Because this analysis shows association rather than direction, both ZBP1-to-partner and partner-to-ZBP1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, GMEB1 grouped by ZBP1-low versus ZBP1-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ZBP1→partner) and Y-score (partner→ZBP1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	GMEB1 →	+0.290	+1.584	.003	.005	3	3
UCEC	CTU2 →	+0.568	+2.443	<.001	<.001	3	3
UCEC	IP6K1 →	+0.312	+2.147	.003	.009	3	3
UCEC	NCAPH2 →	+0.618	+2.432	<.001	<.001	3	3
UCEC	YRDC →	+0.362	+2.526	.003	.001	3	3
SKCM	ATAD3A →	+0.659	+3.119	<.001	<.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 3,333 associations by consensus.

GMEB1 by ZBP1 expression — UCEC

Explore this box plot interactively →