ZBP1

Across TCGA pan-cancer cohorts, ZBP1 RNA differs between tumor and matched normal tissue in 9 of 18 cancer types tested, making tumor–normal expression one of ZBP1’s most consistent transcriptional readouts.

The strongest signal is observed in kidney renal clear cell carcinoma (KIRC), where ZBP1 RNA is more highly expressed in tumor relative to normal tissue. In most cancer types ZBP1 is over-expressed in tumor.

KIRC, HNSC, and LUAD are the cancer types where ZBP1 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in ZBP1 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
KIRC	Male	IV	+0.780	<.001	11	view →
HNSC	All	III,IV	+0.686	<.001	11	view →
LUAD	Female	All	+0.701	<.001	5	view →
STAD	All	All	+0.756	.011	4	view →
BRCA	All	All	+0.513	<.001	4	view →
ESCA	All	All	+1.482	<.001	3	view →
CHOL	All	All	+0.823	.012	2	view →
THCA	Male	IV	+0.593	.001	2	view →
KIRP	All	All	+0.200	.038	1	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 9 strongest of 9 lineages.

ZBP1–KIRC

Open the KIRC breakdown →