ZBP1

Across TCGA cell cohorts, ZBP1 mutation is significantly associated with the RNA expression of many other genes, with 12 significant associations in total. LUNG_SCLC shows the largest number of these associations.

The most reproducible ZBP1-associated genes across cancer lineages are TBC1D3, RNASE3, and OR1P1. Each is linked with ZBP1 in more than 1 cancer types. Because this analysis shows association rather than direction, both ZBP1-to-partner and partner-to-ZBP1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, TBC1D3 grouped by ZBP1-low versus ZBP1-high in LARGE_INTESTINE.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ZBP1→partner) and Y-score (partner→ZBP1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	TBC1D3 →	+0.080	+4.273	<.001	.006	3	1
CNS	RNASE3 →	+0.068	+3.584	<.001	.003	3	1
LUNG_NSCLC_LUAD	OR1P1 →	+0.030	+4.887	.002	.009	3	1
LUNG_SCLC	OR1M1 →	+0.012	+4.643	<.001	.004	3	1
LUNG_SCLC	OR6B3 →	+0.028	+4.269	<.001	.005	3	1
LUNG_SCLC	ACTL9 →	+0.614	+5.169	<.001	<.001	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 12 associations by consensus.

TBC1D3 by ZBP1 expression — LARGE_INTESTINE

Explore this box plot interactively →