ZAP70

Across TCGA patient cohorts, ZAP70 protein abundance is significantly associated with the RNA expression of many other genes, with 13,719 significant associations in total. LSCC shows the largest number of these associations.

The most reproducible ZAP70-associated genes across cancer lineages are GRAP2, IL2RB, and RASAL3. Each is linked with ZAP70 in more than 9 cancer types. Because this analysis shows association rather than direction, both ZAP70-to-partner and partner-to-ZAP70 results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, ZAP70 versus GRAP2 in HNSC, with a Pearson correlation of 0.63.

protein abundance associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ZAP70→partner) and Y-score (partner→ZAP70) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
HNSC	GRAP2 →	+0.955	+0.657	<.001	<.001	3	10
BRCA	IL2RB →	+1.440	+0.899	<.001	<.001	3	10
UCEC	RASAL3 →	+1.172	+0.567	<.001	<.001	3	10
UCEC	BIN2 →	+1.188	+0.518	<.001	.004	3	10
HNSC	ITK →	+1.315	+0.838	<.001	<.001	3	10
UCEC	CD2 →	+1.964	+0.663	<.001	<.001	3	10

Each partner links to its Q-omics profile. Showing the 6 strongest of 13,719 associations by consensus.

ZAP70 vs GRAP2 — HNSC

Explore this scatter interactively →