ZAP70

Across TCGA pan-cancer cohorts, ZAP70 RNA is linked to patient survival in 25 of 34 cancer types, making it the most broadly survival-associated ZAP70 data layer compared with 8 for mutation status and 6 for mass-spec protein.

The strongest signal is observed in head and neck squamous cell carcinoma (HNSC), where higher ZAP70 RNA is associated with better overall survival. In most high-consensus cancer types, elevated ZAP70 expression acts as an unfavorable survival marker, although some lineages such as HNSC and UCEC show a favorable association.

HNSC, UCEC, and SKCM are the cancer types where ZAP70 RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
HNSC	OS	Median	All	0.729	0.592	<.001	146	view →
UCEC	OS	Median	All	0.768	0.580	<.001	124	view →
SKCM	OS	Tertile	All	0.445	0.267	<.001	87	view →
BLCA	OS	Tertile	III,IV	0.748	0.585	.002	80	view →
CESC	DFS	Median	All	0.630	0.435	<.001	72	view →
UVM	OS	Tertile	II,III,IV	0.366	0.699	<.001	65	view →
LGG	DFS	Median	All	0.640	0.819	<.001	51	view →
BRCA	DFS	Tertile	All	0.581	0.499	.015	38	view →
LUAD	OS	Tertile	All	0.866	0.758	.002	38	view →
KIRC	OS	Median	All	0.566	0.736	.001	36	view →
LIHC	DFS	Quartile	All	0.434	0.220	<.001	32	view →
PAAD	DFS	Quartile	II,III,IV	0.598	0.357	.009	20	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 25 lineages.

ZAP70–HNSC (OS)

Open the HNSC breakdown →