ZAP70

Across TCGA pan-cancer cohorts, ZAP70 RNA differs between tumor and matched normal tissue in 5 of 18 cancer types tested, making tumor–normal expression one of ZAP70’s most consistent transcriptional readouts.

The strongest signal is observed in kidney renal clear cell carcinoma (KIRC), where ZAP70 RNA is more highly expressed in tumor relative to normal tissue. In most cancer types ZAP70 is over-expressed in tumor, although a few such as LUSC and THCA show the opposite, repressed pattern.

KIRC, LUSC, and STAD are the cancer types where ZAP70 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in ZAP70 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
KIRC	Male	IV	+1.551	<.001	11	view →
LUSC	All	II,III,IV	−0.923	<.001	6	view →
STAD	All	All	+0.761	.017	6	view →
THCA	All	IV	+0.607	.020	1	view →
THCA	All	All	−0.475	.044	1	view →
KIRP	All	All	+0.423	.029	1	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 6 strongest of 5 lineages.

ZAP70–KIRC

Open the KIRC breakdown →