ZAP70

Across TCGA patient cohorts, ZAP70 mutation is significantly associated with the total protein of many other genes, with 54 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible ZAP70-associated genes across cancer lineages are Caspase-7-cleavedD198, Bax, and eIF4E. Each is linked with ZAP70 in more than 4 cancer types. Because this analysis shows association rather than direction, both ZAP70-to-partner and partner-to-ZAP70 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Caspase-7-cleavedD198 grouped by ZAP70-low versus ZAP70-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ZAP70→partner) and Y-score (partner→ZAP70) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	Caspase-7-cleavedD198 →	+0.938	+2.502	<.001	.001	3	5
COAD	Bax →	+0.160	+1.330	.039	.045	3	3
UCEC	eIF4E →	+0.220	+3.000	.002	<.001	3	2
COAD	mTOR_pS2448 →	-0.178	-3.304	.003	.009	3	2
UCEC	PDCD4 →	-0.504	-1.514	.001	.015	3	2
COAD	RAD51 →	+0.108	+3.169	.047	.017	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 54 associations by consensus.

Caspase-7-cleavedD198 by ZAP70 expression — UCEC

Explore this box plot interactively →