ZAP70

Across TCGA cell cohorts, ZAP70 RNA expression is significantly associated with the go_rna of many other GO terms, with 3,847 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible ZAP70-associated GO terms across cancer lineages are Regulation of myoblast fusion, Negative regulation of myoblast fusion, and Negative regulation of syncytium formation by plasma membrane fusion. Each is linked with ZAP70 in more than 9 cancer types. Because this analysis shows association rather than direction, both ZAP70-to-partner and partner-to-ZAP70 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Regulation of myoblast fusion grouped by ZAP70-low versus ZAP70-high in OESOPHAGUS.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (ZAP70→partner) and Y-score (partner→ZAP70) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OESOPHAGUS	Regulation of myoblast fusion →	+0.164	+0.357	<.001	.006	3	9
OESOPHAGUS	Negative regulation of myoblast fusion →	+0.174	+0.360	<.001	.005	3	9
OESOPHAGUS	Negative regulation of syncytium formation by plasma membrane fusion →	+0.172	+0.382	<.001	.003	3	9
OESOPHAGUS	Cytoplasmic translation →	+0.134	+0.370	<.001	.004	3	9
URINARY_TRACT	Negative regulation of binding →	+0.085	+0.157	.003	.001	3	9
SOFT_TISSUE	Viral transcription →	+0.105	+0.197	<.001	.002	2	9

Each partner links to its Q-omics profile. Showing the 6 strongest of 3,847 associations by consensus.

Regulation of myoblast fusion by ZAP70 expression — OESOPHAGUS

Explore this box plot interactively →