ZAP70

Across TCGA cell cohorts, ZAP70 mutation is significantly associated with the RNA expression of many other genes, with 744 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible ZAP70-associated genes across cancer lineages are F11, CLEC2A, and LYZL2. Each is linked with ZAP70 in more than 1 cancer types. Because this analysis shows association rather than direction, both ZAP70-to-partner and partner-to-ZAP70 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, F11 grouped by ZAP70-low versus ZAP70-high in LARGE_INTESTINE.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ZAP70→partner) and Y-score (partner→ZAP70) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	F11 →	+0.035	+2.660	<.001	<.001	3	2
OESOPHAGUS	CLEC2A →	+0.152	+4.857	<.001	<.001	3	1
LUNG_SCLC	LYZL2 →	+0.026	+5.643	<.001	.002	3	1
BLOOD_Lymphoma	CER1 →	+0.024	+4.643	<.001	.005	3	1
BLOOD_Lymphoma	PGK2 →	+0.045	+4.523	<.001	.004	3	1
BLOOD_Lymphoma	OR2M7 →	+0.055	+5.247	<.001	.001	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 744 associations by consensus.

F11 by ZAP70 expression — LARGE_INTESTINE

Explore this box plot interactively →