YY1

Across TCGA patient cohorts, YY1 protein abundance is significantly associated with the RNA expression of many other genes, with 12,978 significant associations in total. LSCC shows the largest number of these associations.

The most reproducible YY1-associated genes across cancer lineages are NRDE2, NEK9, and XRCC3. Each is linked with YY1 in more than 6 cancer types. Because this analysis shows association rather than direction, both YY1-to-partner and partner-to-YY1 results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, YY1 versus NRDE2 in HNSC, with a Pearson correlation of 0.35.

protein abundance associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (YY1→partner) and Y-score (partner→YY1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
HNSC	NRDE2 →	+0.434	+0.266	<.001	<.001	3	7
BRCA	NEK9 →	+0.495	+0.235	<.001	.002	3	6
LSCC	XRCC3 →	+0.602	+0.342	<.001	<.001	3	6
BRCA	KLHDC2 →	+0.579	+0.283	<.001	<.001	3	6
BRCA	TTC8 →	+0.546	+0.184	<.001	.001	3	6
BRCA	MTA1 →	+0.718	+0.266	<.001	<.001	3	6

Each partner links to its Q-omics profile. Showing the 6 strongest of 12,978 associations by consensus.

YY1 vs NRDE2 — HNSC

Explore this scatter interactively →