YY1

Across TCGA pan-cancer cohorts, YY1 RNA differs between tumor and matched normal tissue in 13 of 18 cancer types tested, making tumor–normal expression one of YY1’s most consistent transcriptional readouts.

The strongest signal is observed in head and neck squamous cell carcinoma (HNSC), where YY1 RNA is more highly expressed in tumor relative to normal tissue. In most cancer types YY1 is over-expressed in tumor, although a few such as THCA and KICH show the opposite, repressed pattern.

HNSC, LIHC, and THCA are the cancer types where YY1 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in YY1 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
HNSC	Female	III,IV	+0.945	<.001	12	view →
LIHC	Male	II,III,IV	+0.780	<.001	9	view →
THCA	All	III,IV	−0.398	<.001	9	view →
STAD	Male	II,III,IV	+0.748	<.001	7	view →
LUSC	Male	II,III,IV	+0.611	<.001	6	view →
BLCA	All	All	+0.362	.005	6	view →
CHOL	Male	All	+1.408	<.001	5	view →
ESCA	All	All	+0.636	.002	5	view →
COAD	Male	All	+0.258	.001	5	view →
KICH	All	All	−0.505	<.001	4	view →
KIRP	All	II,III,IV	+0.361	.018	3	view →
KIRC	All	All	+0.150	.018	2	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 12 strongest of 13 lineages.

YY1–HNSC

Open the HNSC breakdown →