YY1

Across TCGA pan-cancer cohorts, YY1 RNA is linked to patient survival in 27 of 34 cancer types, making it the most broadly survival-associated YY1 data layer compared with 5 for mutation status and 7 for mass-spec protein.

The strongest signal is observed in adrenocortical carcinoma (ACC), where higher YY1 RNA is associated with worse disease-free survival. In most high-consensus cancer types, elevated YY1 expression acts as an unfavorable survival marker, although some lineages such as THYM and KIRC show a favorable association.

ACC, KIRP, and LIHC are the cancer types where YY1 RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
ACC	DFS	Median	All	0.385	0.783	<.001	76	view →
KIRP	OS	Tertile	III,IV	0.314	0.750	.003	52	view →
LIHC	OS	Tertile	All	0.681	0.843	<.001	51	view →
UVM	DFS	Tertile	III,IV	0.233	0.860	.001	42	view →
THYM	DFS	Tertile	All	0.872	0.616	.003	36	view →
KIRC	OS	Tertile	All	0.723	0.528	<.001	36	view →
UCEC	DFS	Tertile	All	0.781	0.880	.002	30	view →
GBM	DFS	Median	All	0.404	0.175	<.001	24	view →
LUAD	OS	Quartile	All	0.768	0.902	.011	19	view →
HNSC	OS	Tertile	All	0.262	0.551	.002	17	view →
STAD	OS	Median	II,III,IV	0.623	0.724	.021	16	view →
OV	DFS	Median	All	0.192	0.130	.029	14	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 27 lineages.

YY1–ACC (DFS)

Open the ACC breakdown →