YWHAEP5

Across TCGA patient cohorts, YWHAEP5 mutation is significantly associated with the total protein of many other genes, with 10 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible YWHAEP5-associated genes across cancer lineages are Notch1, p62 Lck ligand, and ARID1A. Each is linked with YWHAEP5 in more than 1 cancer types. Because this analysis shows association rather than direction, both YWHAEP5-to-partner and partner-to-YWHAEP5 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Notch1 grouped by YWHAEP5-low versus YWHAEP5-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (YWHAEP5→partner) and Y-score (partner→YWHAEP5) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	Notch1 →	+0.197	+3.169	.010	.020	3	1
UCEC	p62 Lck ligand →	+0.601	+3.179	<.001	.010	3	1
UCEC	ARID1A →	-0.249	-3.162	.012	.019	3	1
UCEC	VHL →	-1.482	-3.000	<.001	.036	3	1
UCEC	Caspase-8 →	-0.314	-2.973	.022	.035	3	1
UCEC	EGFR_pY1068 →	-0.324	-3.169	.018	.020	2	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 10 associations by consensus.

Notch1 by YWHAEP5 expression — UCEC

Explore this box plot interactively →