YWHAEP5

Across TCGA pan-cancer cohorts, YWHAEP5 RNA is linked to patient survival in 24 of 34 cancer types, making it the most broadly survival-associated YWHAEP5 data layer compared with 1 for mutation status.

The strongest signal is observed in kidney renal clear cell carcinoma (KIRC), where higher YWHAEP5 RNA is associated with better overall survival. In most high-consensus cancer types, elevated YWHAEP5 expression acts as an unfavorable survival marker, although some lineages such as KIRC and BRCA show a favorable association.

KIRC, BRCA, and UCS are the cancer types where YWHAEP5 RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
KIRC	OS	Median	All	0.715	0.548	<.001	100	view →
BRCA	DFS	Tertile	III,IV	0.959	0.822	<.001	44	view →
UCS	OS	Median	IV	0.732	0.224	.018	36	view →
BLCA	OS	Tertile	II,III,IV	0.302	0.459	.007	34	view →
LUAD	DFS	Quartile	III,IV	0.258	0.649	.002	24	view →
READ	DFS	Quartile	All	0.845	0.306	.001	21	view →
MESO	OS	Median	IV	0.283	0.748	.005	19	view →
ACC	DFS	Quartile	III,IV	0.684	0.075	.006	17	view →
HNSC	OS	Tertile	All	0.323	0.624	.006	16	view →
SARC	OS	Tertile	All	0.397	0.625	<.001	16	view →
CESC	OS	Median	II,III,IV	0.883	0.760	.018	14	view →
OV	OS	Quartile	IV	0.909	0.602	.021	12	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 24 lineages.

YWHAEP5–KIRC (OS)

Open the KIRC breakdown →