YWHAE

Across TCGA patient cohorts, YWHAE mutation is significantly associated with the total protein of many other genes, with 7 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible YWHAE-associated genes across cancer lineages are Ku80, MEK1, and Src_pY416. Each is linked with YWHAE in more than 1 cancer types. Because this analysis shows association rather than direction, both YWHAE-to-partner and partner-to-YWHAE results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Ku80 grouped by YWHAE-low versus YWHAE-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (YWHAE→partner) and Y-score (partner→YWHAE) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	Ku80 →	+0.281	+3.009	.013	.019	3	1
UCEC	MEK1 →	+0.393	+2.459	.026	.019	3	1
UCEC	Src_pY416 →	-0.234	-3.169	.044	.019	3	1
UCEC	Tuberin →	+0.418	+2.459	.001	.020	3	1
UCEC	INPP4B →	-0.360	-3.000	.021	.036	2	1
UCEC	p62 Lck ligand →	+0.511	+2.459	.001	.020	2	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 7 associations by consensus.

Ku80 by YWHAE expression — UCEC

Explore this box plot interactively →