YWHAE

Across TCGA cell cohorts, YWHAE RNA expression is significantly associated with the go_rna of many other GO terms, with 3,978 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible YWHAE-associated GO terms across cancer lineages are DNA-templated transcription initiation, Negative regulation of chromosome organization, and Centrosome separation. Each is linked with YWHAE in more than 14 cancer types. Because this analysis shows association rather than direction, both YWHAE-to-partner and partner-to-YWHAE results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, DNA-templated transcription initiation grouped by YWHAE-low versus YWHAE-high in BREAST.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (YWHAE→partner) and Y-score (partner→YWHAE) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BREAST	DNA-templated transcription initiation →	+0.063	+0.769	<.001	<.001	3	15
UPPER_AERODIGESTIVE_TRACT	Negative regulation of chromosome organization →	+0.132	+1.069	<.001	<.001	3	14
STOMACH	Centrosome separation →	+0.125	+0.719	.002	.004	3	14
BREAST	Positive regulation of transcription initiation by RNA polymerase II →	+0.068	+0.821	<.001	<.001	3	14
KIDNEY	Regulation of transcription initiation by RNA polymerase II →	+0.074	+0.663	<.001	.005	2	15
SOFT_TISSUE	Chromosome condensation →	+0.173	+0.861	<.001	<.001	3	14

Each partner links to its Q-omics profile. Showing the 6 strongest of 3,978 associations by consensus.

DNA-templated transcription initiation by YWHAE expression — BREAST

Explore this box plot interactively →