YWHAB

Across TCGA patient cohorts, YWHAB mutation is significantly associated with the RNA expression of many other genes, with 908 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible YWHAB-associated genes across cancer lineages are FAM223A, RN7SL248P, and RNU7-169P. Each is linked with YWHAB in more than 1 cancer types. Because this analysis shows association rather than direction, both YWHAB-to-partner and partner-to-YWHAB results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, FAM223A grouped by YWHAB-low versus YWHAB-high in BRCA.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (YWHAB→partner) and Y-score (partner→YWHAB) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BRCA	FAM223A →	+0.102	+5.800	<.001	.003	3	2
UCEC	RN7SL248P →	+0.073	+3.500	<.001	.002	3	2
LGG	RNU7-169P →	+0.634	+5.602	<.001	.004	3	2
BRCA	SNORA10B →	+0.444	+5.441	<.001	.005	3	2
LUAD	RNA5SP391 →	+0.248	+7.930	<.001	.008	3	2
UCEC	LIN7C →	+0.533	+3.593	.009	.001	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 908 associations by consensus.

FAM223A by YWHAB expression — BRCA

Explore this box plot interactively →