YWHAB

Across TCGA pan-cancer cohorts, YWHAB RNA differs between tumor and matched normal tissue in 12 of 18 cancer types tested, making tumor–normal expression one of YWHAB’s most consistent transcriptional readouts.

The strongest signal is observed in head and neck squamous cell carcinoma (HNSC), where YWHAB RNA is more highly expressed in tumor relative to normal tissue. In most cancer types YWHAB is over-expressed in tumor, although a few such as KIRC and KICH show the opposite, repressed pattern.

HNSC, LIHC, and STAD are the cancer types where YWHAB tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in YWHAB RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
HNSC	All	III,IV	+0.629	<.001	11	view →
LIHC	Female	II,III,IV	+1.093	<.001	9	view →
STAD	All	II,III,IV	+0.922	<.001	9	view →
BLCA	All	III,IV	+0.477	<.001	7	view →
BRCA	All	III,IV	+0.769	<.001	6	view →
CHOL	All	II,III,IV	+2.425	<.001	5	view →
KIRC	All	II,III,IV	−0.284	.001	5	view →
KICH	All	All	−0.612	<.001	4	view →
COAD	Male	II,III,IV	+0.592	.001	4	view →
READ	All	III,IV	+0.554	.005	2	view →
THCA	Male	III,IV	−0.252	.035	2	view →
ESCA	All	All	+0.991	.011	1	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 12 strongest of 12 lineages.

YWHAB–HNSC

Open the HNSC breakdown →