YKT6

Across TCGA patient cohorts, YKT6 mutation is significantly associated with the RNA expression of many other genes, with 29 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible YKT6-associated genes across cancer lineages are MIR4659A, PGBD4P2, and RNA5SP411. Each is linked with YKT6 in more than 1 cancer types. Because this analysis shows association rather than direction, both YKT6-to-partner and partner-to-YKT6 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, MIR4659A grouped by YKT6-low versus YKT6-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (YKT6→partner) and Y-score (partner→YKT6) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	MIR4659A →	+0.742	+3.418	<.001	.009	3	2
READ	PGBD4P2 →	+0.162	+6.257	<.001	.001	3	1
UCEC	RNA5SP411 →	+2.785	+3.393	<.001	.007	3	1
UCEC	RN7SL495P →	+0.135	+4.335	.004	.007	3	1
READ	TMEM225 →	+0.114	+5.039	<.001	.008	3	1
READ	RNU6-1274P →	+0.547	+5.925	<.001	.002	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 29 associations by consensus.

MIR4659A by YKT6 expression — UCEC

Explore this box plot interactively →