YKT6

Across TCGA pan-cancer cohorts, YKT6 RNA is linked to patient survival in 27 of 34 cancer types, making it the most broadly survival-associated YKT6 data layer compared with 2 for mutation status and 6 for mass-spec protein.

The strongest signal is observed in head and neck squamous cell carcinoma (HNSC), where higher YKT6 RNA is associated with worse disease-free survival. In most high-consensus cancer types, elevated YKT6 expression acts as an unfavorable survival marker, although some lineages such as SCLC and DLBC show a favorable association.

HNSC, MESO, and KICH are the cancer types where YKT6 RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
HNSC	DFS	Median	All	0.531	0.671	<.001	152	view →
MESO	OS	Median	All	0.274	0.492	<.001	109	view →
KICH	DFS	Tertile	III,IV	0.172	1.000	<.001	106	view →
BLCA	DFS	Tertile	II,III,IV	0.458	0.622	.001	78	view →
ACC	OS	Median	All	0.663	0.915	<.001	75	view →
CESC	OS	Tertile	All	0.709	0.880	.001	72	view →
LIHC	OS	Median	All	0.583	0.778	<.001	62	view →
KIRC	DFS	Quartile	All	0.774	0.916	.010	62	view →
LGG	DFS	Median	All	0.649	0.822	<.001	51	view →
LUAD	DFS	Median	All	0.737	0.840	<.001	50	view →
UVM	DFS	Median	All	0.376	0.746	.001	31	view →
PAAD	DFS	Quartile	All	0.318	0.666	.001	29	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 27 lineages.

YKT6–HNSC (DFS)

Open the HNSC breakdown →