XRCC4

Across TCGA patient cohorts, XRCC4 RNA expression is significantly associated with the protein abundance of many other proteins, with 7,384 significant associations in total. CCRCC shows the largest number of these associations.

The most reproducible XRCC4-associated proteins across cancer lineages are HSPA4, DHFR, and TSPO. Each is linked with XRCC4 in more than 3 cancer types. Because this analysis shows association rather than direction, both XRCC4-to-partner and partner-to-XRCC4 results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, XRCC4 versus HSPA4 in BRCA, with a Pearson correlation of 0.27.

RNA expression associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (XRCC4→partner) and Y-score (partner→XRCC4) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BRCA	HSPA4 →	+0.252	+0.384	.006	.004	3	4
LUAD	DHFR →	+0.519	+0.328	.002	.001	3	4
GBM	TSPO →	-0.655	-0.266	<.001	.002	3	3
BRCA	SETD2_S744 →	-0.844	-0.689	<.001	.002	3	3
OV	CHD1 →	+0.377	+0.762	<.001	<.001	2	4
CCRCC	LNPEP →	+0.401	+0.445	<.001	<.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 7,384 associations by consensus.

XRCC4 vs HSPA4 — BRCA

Explore this scatter interactively →