XRCC4

Across TCGA pan-cancer cohorts, XRCC4 RNA is linked to patient survival in 27 of 34 cancer types, making it the most broadly survival-associated XRCC4 data layer compared with 3 for mutation status and 6 for mass-spec protein.

The strongest signal is observed in kidney renal clear cell carcinoma (KIRC), where higher XRCC4 RNA is associated with better overall survival. In most high-consensus cancer types, elevated XRCC4 expression acts as an unfavorable survival marker, although some lineages such as KIRC and SKCM show a favorable association.

KIRC, UVM, and OV are the cancer types where XRCC4 RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
KIRC	OS	Tertile	All	0.695	0.493	<.001	85	view →
UVM	DFS	Quartile	III,IV	0.170	0.814	.001	55	view →
OV	DFS	Tertile	All	0.312	0.418	.004	52	view →
KIRP	DFS	Median	All	0.876	0.953	.005	44	view →
LIHC	DFS	Median	All	0.311	0.516	.004	37	view →
STAD	DFS	Median	IV	0.199	0.644	.010	32	view →
BRCA	OS	Median	II,III,IV	0.491	0.619	<.001	32	view →
LGG	DFS	Median	All	0.661	0.850	<.001	29	view →
PAAD	DFS	Tertile	All	0.165	0.396	.004	25	view →
KICH	DFS	Median	II,III,IV	0.719	0.958	.018	24	view →
HNSC	OS	Median	All	0.598	0.806	<.001	22	view →
SKCM	OS	Tertile	III,IV	0.892	0.737	.005	19	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 27 lineages.

XRCC4–KIRC (OS)

Open the KIRC breakdown →