XIST

Across TCGA patient cohorts, XIST mutation is significantly associated with the total protein of many other genes, with 73 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible XIST-associated genes across cancer lineages are NF2, Rad50, and beta-Catenin. Each is linked with XIST in more than 4 cancer types. Because this analysis shows association rather than direction, both XIST-to-partner and partner-to-XIST results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, NF2 grouped by XIST-low versus XIST-high in BLCA.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (XIST→partner) and Y-score (partner→XIST) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLCA	NF2 →	+0.158	+2.999	.044	.035	3	5
LUSC	Rad50 →	+0.081	+1.594	.038	.002	3	4
STAD	beta-Catenin →	+0.735	+2.459	.019	.019	3	3
UCEC	TFRC →	+0.426	+1.847	.002	.007	3	3
LUAD	cIAP →	+0.077	+2.618	.026	.004	3	3
UCEC	Cyclin-B1 →	+0.498	+2.000	<.001	<.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 73 associations by consensus.

NF2 by XIST expression — BLCA

Explore this box plot interactively →